2024 Tmed10蛋白

Tmed10蛋白

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August undefined, 2024

WebHere, we find a protein translocation pathway regulating leaderless cargo entry into the vesicle carrier in UPS. We identified a transmembrane protein transmembrane emp24 domain-containing protein 10 (TMED10)/TMP21 as a regulatory factor for the secretion of multiple cargoes, including the mature form of interleukin 1(IL-1) family members and a … WebMar 18, 2024 · Go to Variation Viewer for TMED10 variants; Summary. This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric …

TMED10 transmembrane p24 trafficking protein 10 [ Homo …

WebInteracts with ARF1 (GDP-bound); the interaction probably involves a TMED10 oligomer (PubMed:11726511). Interacts with SEC23A, SEC24B, SEC24C and SEC24D components … http://www.larc.tsinghua.edu.cn/post/1056 restored cars

TMED10抗体 TMED10 antibody-一抗-艾美捷科技有限公司

http://www.biofeng.com/gene/renyuan/TMED10.html WebOct 10, 2024 · When addressing the role of TMED2 and TMED10 in pore formation, we found that PA fails to oligomerize in TMED2- and/or TMED10-depleted cells (Figures 1 F, 1G, S1 F, and S1G). This was determined by an in vitro acid pulse, where cell lysates are treated with acidic buffer to trigger the conversion of all oligomers to SDS-resistant PA pore . WebTMED10. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas … restored cars 1930s

A Translocation Pathway for Vesicle-Mediated Unconventional

WebApr 30, 2024 · In the cell, TMED10 localizes on the endoplasmic reticulum (ER)-Golgi intermediate compartment and directs the entry of cargoes into this compartment. … Web课题组主要方向为非经典蛋白质分泌（ups）的分子机制及在人类疾病中的功能。 ... 现阶段的研究工作主要集中于：1）tmed10蛋白转运体介导的非经典蛋白质分泌 (thu)在疾病中功能和分子机制；2）针对thu通路或ups潜在的靶向炎症和衰老相关疾病的药物筛选。 restored cabooseWebMar 18, 2024 · TMED10transmembrane p24 trafficking protein 10. Gene ID: 10972, updated on 6-Nov-2024. Gene type: protein coding. Also known as: p23; TMP21; p24d1; S31I125; … restored cars for sale near me

"WebThe p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes ( PubMed: 10052452 ). Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation ... " - Tmed10蛋白

Tmed10蛋白

A Translocation Pathway for Vesicle-Mediated ... - ScienceDirect

Web研究人员进行了体外重组实验表明，tmed10直接介导ups货物转运进入脂质体内，这依赖于蛋白质的去折叠，并由分子伴侣hsp90a和hsp90sb1促进其转运。在细胞中，TMED10定位 … Web丁香通为您提供MONOCARBOXTR商品详情介绍：价格：￥3439，货号：AB3320P，品牌：merck millipore，供应商：欣博盛，详见丁香通MONOCARBOXTR商品详情页；

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Web细胞实验发现，TMED10能够调控大量非经典分泌蛋白的分泌，包括炎症因子IL-1家族成员，galectin1和galectin3，以及小分子伴侣蛋白HSP5B。 CLP诱导的败血性休克（Cecal … WebApr 30, 2024 · 通过针对这些非经典分泌蛋白的序列比对，研究团队发现了一个共同的基序motif1，并利用体外脂质体重建实验系统，验证了TMED10具有直接转运非经典分泌蛋白进入膜泡的通道蛋白活性，同时揭示了其在细胞内的定位（ERGIC）、鉴定了相关分子伴侣蛋白(HSP90)，提出 ...

WebMay 1, 2010 · Since mutant embryos lacking TMED10 arrest and die prior to implantation at E4.5 (Denzel et al., 2000), whereas Tmed2 mutants survive up to E10.5, TMED10 expression and function must be independent of stable, zygotic expression of Tmed2 in the pre-implantation mouse embryo. These findings indicate that individual members of the … WebMar 10, 2024 · The physiological interaction between TMED10 and ALK5 prompted us to examine their subcellular colocalization. When human embryonic retinoblast 911 cells were transfected with both TMED10 and ALK5, both of them could be seen mainly in the cytosol (Fig. 1F, upper panels), because both proteins are synthesized in the rough endoplasmic …

WebApr 30, 2024 · TMED10 associated with mIL-1β in co-immunoprecipitations (coIPs) (Figures 2 A and 2B).As positive controls, mIL-1β or TMED10 associate with HSP90A or TMED9, respectively (Figures 2 A and 2B), which is consistent with the previous data (Füllekrug et al., 1999, Zhang et al., 2015).Endogenous TMED10 and mIL-1β associated in … WebNov 6, 2024 · Title: Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation. Study validated EXT1, TM9SF2, and TMED10 as important host factors for vaccinia virus infection. In addition, TMED10 was found to be crucial for virus-induced plasma membrane blebbing and phosphatidylserine-induced micropinocytosis.

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WebP24 protein family is a group of transmembrane proteins that are major components of COPI and COPII-coated vesicles.The family is also known as EMP24/GP25L/p24 family and TMP21-like proteins.The latter naming was after transmembrane emp24 domain-containing protein 10 that was found in the human brain.It was claimed to block the beta-amyloid … proxyscan.ioWebApr 30, 2024 · 在国家自然科学基金项目（批准号：91854114）等资助下，清华大学生命科学院葛亮课题组发现跨膜转运体蛋白TMED10参与诸多非经典分泌蛋白的跨膜转运，揭示了 … proxy scanner githubWebApr 8, 2024 · 研究人员将tmed10鉴定为许多无导向货物的囊泡进入和分泌的蛋白质通道。 TMED10 C末端区域与货物中基序的相互作用说明了货物的选择性释放。 restored charityWebDec 27, 2024 · Similarly, deletion of exon 1 of mouse Tmed10 results in loss of TMED10 protein and embryonic lethality at E3.5, before implantation (Denzel et al., 2000). Thus, TMED2 and TMED10 have non-redundant functions during embryogenesis. Tmed2 mRNA is expressed in a temporal and a tissue-specific pattern in mice (Jerome-Majewska et al., … proxyscape online proxyWeb机制在于，circATG4B可编码一种新的蛋白质（circATG4B-222aa）与TMED10互作，阻止TMED10与ATG4B结合，从而导致自噬增加，继而诱导L-OHP耐药。研究揭示了外泌 … proxy scanner downloadWebApr 8, 2024 · 在体外重建测定中，tmed10直接介导无导向货物进入脂质体的膜转运，这取决于蛋白的解折叠和hsp90的增强。在细胞中，tmed10位于内质网与高尔基体的 ... proxy scanner onlineWebMar 21, 2024 · GeneCards Summary for TMED10 Gene. TMED10 (Transmembrane P24 Trafficking Protein 10) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Golgi-to-ER retrograde transport . Gene Ontology (GO) annotations related to this gene include protein-containing complex … restored chica