Tebulin
WebClass III beta-tubulin (TUBB3) reduces microtubule stability and confers resistance to microtubule-stabilizing taxanes, including paclitaxel and docetaxel. Pancreatic ductal adenocarcinomas show limited responsiveness to taxanes, but little is known of the underlying mechanisms. The aim of this study was to examine TUBB3 expression in ... Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily. α- and β-tubulins polymerize into microtubules, a major component of the eukaryotic cytoskeleton. Microtubules function in many essential cellular processes, … See more Tubulin is characterized by the evolutionarily conserved Tubulin/FtsZ family, GTPase protein domain. This GTPase protein domain is found in all eukaryotic tubulin chains, as well as the bacterial protein … See more Eukaryotic The tubulin superfamily contains six families (alpha-(α), beta-(β), gamma-(γ), delta-(δ), epsilon … See more When incorporated into microtubules, tubulin accumulates a number of post-translational modifications, many of which are unique to these proteins. These modifications include See more • Tubulin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • EC 3.6.5.6 • Protocols for tubulin experiments See more Microtubules α- and β-tubulin polymerize into dynamic microtubules. In eukaryotes, microtubules are one of the major components of the cytoskeleton, … See more Tubulins are targets for anticancer drugs such as vinblastine and vincristine, and paclitaxel. The anti-worm drugs mebendazole and albendazole as well as the anti-gout agent colchicine bind to tubulin and inhibit microtubule formation. While the former … See more • Biology portal • Motor protein • Kinesin • Dynein See more
Tebulin
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WebJun 1, 2006 · In animal cells, γ-tubulin forms ring structures in the PCM that are associated with the minus ends of newly polymerized microtubules. The outer diameter of the γ-tubulin complex is similar to the outer diameter of a microtubule, and this is thought to provide a base for the assembly of α/β-tubulin dimers ( Moritz et al., 1995; Zheng et al ... WebThus, as previously we reported in one of our patients with Naxos disease, the enhanced automaticity of ectopic foci and/or reentry circuit around the scar tissue was abolished by cytoskeletal disruption mechanism, induced by tubulin destabilization with low-dose colchicines.6 Additionally interesting, colchicine also upregulates other proteins involved …
WebTubulin is a highly conserved αβ dimeric protein present and is essential for all eukaryotes. αβ-Tubulin dimers assemble into microtubules, dynamic polymers important in a variety of functions, most noticeably, mitosis. Tubulin assembly and disassembly are linked to guanosine triphosphate hydrolysis. A variety of proteins interact with ... WebApr 14, 2024 · The present study embodies exploration of new potential targets for bioactive azapodophyllotoxins (AZP) that have been mainly considered as inhibitor of tubulin polymerization and topoisomerases. The interaction of a novel AZP, HTDQ, with potential target DNA (calf thymus DNA) has been investigated alongwith its mechanism of action …
WebTubulin is a highly conserved αβ dimeric protein present and is essential for all eukaryotes. αβ-Tubulin dimers assemble into microtubules, dynamic polymers important in a variety of functions, most noticeably, mitosis. Tubulin assembly and disassembly are linked to guanosine triphosphate hydrolysis. A variety of proteins interact with ... WebConfocal immunofluorescent analysis of NIH-3T3 cells, using α/β-Tubulin Antibody (green) and Phospho-Histone H3 (Ser10) (6G3) Mouse mAb #9706 (red) showing different stages of the cell cycle. Flow cytometric …
WebMar 29, 2024 · Last Editorial Review: 3/29/2024. Tuberculin: A protein extracted from Mycobacterium tuberculosis that is used in a skin test to determine if a person has been exposed to tuberculosis. The tuberculin preparation in most common use today is purified protein derivative (PPD) tuberculin. PPD is injected (or multiple-punctured) into the skin.
WebA Clinical Evaluation Comparing the Combining of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer - Full Text View. uncrc reporting scotlandWebA) Schematic representation of a microtubule. B) Electron micrograph of in vitro assembled bovine microtubules (11,000 x magnification). Tubulin polymerization can be followed by using a spectrophotometer. The ability of tubulin to polymerize into microtubules can be followed very simply by observing an increase in optical density of a tubulin solution at … thorsten twillingWebJul 5, 2004 · Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound … thorsten uheWebAmong the PTMs, acetylation of K40 in α-tubulin (α-Ac-Tub) is the sole PTM to characterize the luminal surface of MTs. 13, 14 In mammals, the levels of α-Ac-Tub are regulated by acetylation and deacetylation, which are catalyzed by α-tubulin acetyltransferase 1 (αTAT1, also known as Mec17) and histone deacetylase 6 (HDAC6), respectively ... uncrc rights and participationWebTubulin is a "heterodimer" protein, meaning it is comprised of a pair of polypeptide chains -- called monomers -- that differ in the sequence of their amino acids. The model presented by Nogales, Wolf, and Downing, shows that each tubulin monomer -- the alpha and the beta -- is a compact molecular structure with three functional components or ... uncrc reporting ukWebAbstract. In most eukaryotes, families of tubulin genes give rise to multiple isoforms of tubulin, which may be modified post-translationally. The synthesis of isotubulins is spatially and temporally regulated, leading to the presence of different tubulins within an organism. The cellular localization of tubulin is also nonrandom with discrete ... thorsten ulbrichWebFeb 17, 2024 · Target-based assays established the inhibition of tubulin polymerization by 12j at an IC 50 value of 5.65 ± 0.05 μM and its effective binding with circulating tumor DNA as a DNA intercalator. The detailed binding interactions of 12j with tubulin and DNA were examined by docking studies on PDB ID: 3E22 and DNA hexamer (PDB ID: 1NAB), … thorsten uhe sylt