NettetSmooth muscle cells, also known as smooth myocytes, isolated from tissues such as human ascending (thoracic) and descending (abdominal) aorta, coronary artery, and … Nettet1. feb. 2024 · C57BL/6J mice are more susceptible to formation of aneurysms than C57Bl/6N mice. • C57Bl/6J aortic smooth muscle cells have a more synthetic and inflammatory phenotype. • C57Bl/6J smooth muscle cells present higher levels of NADP/NADPH and oxidative DNA modifications.
FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC ...
Nettet27. okt. 2003 · Mouse aortic smooth muscle cells (SMCs) were loaded for 72 h with cholesterol by using cholesterol:methyl-β-cyclodextrin complexes, leading to ≈2-fold … Nettet2. apr. 2024 · The etiology of aortic aneurysms is poorly understood, but it is associated with atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β … liam boots
Smooth Muscle Cell Reprogramming in Aortic Aneurysms - Cell …
Nettet10. jun. 2014 · Tissue explanting method with slight modification was used to isolate the rat aortic smooth muscle cells from the thoracic aorta of 3–5 weeks old SD rats. Briefly, thoracic aorta of SD rat was aseptically isolated under anesthesia, fat and connective tissues surrounding aorta were trimmed, and the aortic vessels were longitudinally cut … NettetSt. Paul et al. show that FXR1 links mRNA processing with actin dynamics in vascular smooth muscle cells by binding to mRNAs and proteins that regulate the cytoskeleton. Deletion of FXR1 leads to decreased cellular migration, adhesion, and contraction. Additionally, mice without FXR1 have decreased blood pressure. NettetRecent evidence showed that autophagy, a catabolic cellular mechanism responsible for nutrient recycling, plays a major role in the physiology of vascular cells such as … liam botting britlift