Hemi-protonated
Web(A) Hemi-protonated C +-C base pair (B) i-motif structure (C) Proposed C-C base pair stabilized by Cu + . Source publication Redox-dependent control of i-Motif DNA structure … Web21 jul. 2024 · i-Motifs are quadruplex DNA structures formed from sequences rich in cytosine and held together by intercalated, hemi-protonated cytosine-cytosine base pairs. These …
Hemi-protonated
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Webi-motifs are noncanonical DNA structures formed via the stack of intercalating hemi-protonated C⁺: C base pairs in C-rich DNA strands and play essential roles in the … Web24 mrt. 2024 · i-motifs are noncanonical DNA structures formed via the stack of intercalating hemi-protonated C +: C base pairs in C-rich DNA strands and play …
WebDue to an acidic environment, this is achieved by hemi-protonated cytosines which mimick an ordinary C-G binding as it is present in double helix DNA. Hence it becomes clear that these structures are only occurring at slightly acidic to neutral conditions resulting in pH values from 4.8 to 7.0 [1, 2, 6]. I-motifs show a remarkable sta- Web22 feb. 2024 · hemi-protonated cytosine–cytosine+ (C:C+)base pairs (Fig-ure 1A).[8,9] i-DNAformation at physiological pH has been recently reported.[10,11] Moreover,the generation of an anti-body able to detect i-DNAhas proved its presence in the nucleus of human cells,arguing for regulatory roles in the genome,e.g.,at proto-oncogene promoters …
Web20 jan. 2012 · We have proposed mechanisms for two key RNA world activities that are compatible with an acidic milieu: (i) non-enzymatic RNA replication of a hemi-protonated cytosine-rich oligonucleotide, and (ii) specific aminoacylation of tRNA/hairpins through triple helix interactions between the helical aminoacyl stem and a single-stranded … WebHemi-Protonated Cytosines i-Motifs are four-stranded secondary structures comprised of two parallel-stranded DNA duplexes zipped together in an antiparallel orientation by intercalated, hemi-protonated cytosine–cytosine base pairs (Fig. 2) (Gehring et al. 1993). The building block of i-motifs is the CC+ base pair, and it is formed by the planar
Web16 sep. 2024 · Generally, to favour the formation of hemi-protonated C·C + base pairs, iM structures are studied in vitro in acidic solutions and possibly in the presence of sodium or potassium ions, whose concentrations vary from 10 to 150 mM.
Web3 dec. 2015 · Similar C-rich sequences may, under acidic conditions, form i-motifs consisting of two parallel duplexes in a head to tail orientation held together by hemi-protonated C + -C pairs. We show that... rockford board of electionsWebhemiprotonated ( not comparable ) protonated at only half of the possible sites (typically, 1 of 2) quotations . This page was last edited on 29 September 2024, at … other games like luckyland slotsWeb22 dec. 1994 · PubMed Abstract: At slightly acid or even neutral pH, oligodeoxynucleotides that include a stretch of cytidines form a tetramer structure in which two parallel-stranded … rockford bobcatWeb8 mei 2024 · We have also demonstrated the versatile ability of this i-motif ligand, i.e., the affinity of C343 towards both intermolecular and intramolecular i-motif DNA differing in the chain lengths, molecularity and sizes, which is observed in various oncogene promoters. other games like hay dayWeb31 jan. 2024 · i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held together by hemi-protonated cytosine-cytosine base pairs. These structures have been utilized extensively as pH-switches in DNA-based nanotechnology. Recently there has been an increasing interest in i-motif struc … other games like osuWeb1 apr. 1998 · We present a high-definition structure of d(5mCCT3CCT3ACCT3CC), a DNA sequence which resembles a four-times repeat of the C-rich strand of telomeres and … other games like jackboxWeb2 dec. 2024 · Abstract I-motifs are non-canonical nucleic acids structures characterized by intercalated H-bonds between hemi-protonated cytosines. Evidence on the involvement … rockford boat vacation \u0026 fishing show