WebCOV77-39 COV78-36 COV91-27 V H gene mutation (%) 5 0 10 15 20 0 5 10 15 20 %VH Mutation Fusion mAbsNT50 (ug/mL) vs %VH mutation [VH Mutation (%)] mAbs 10-3 10-2 10-1 100 101 102 0 20 40 60 80 100 [mAb] µg/mL % Neutralization COV44-62 Neutralization Curves SARS2 WA-1_VRC SARS1_VRC MERS_VRC OC43_2024Mar03 … WebCOV77-04 4-59 COV77-39 4-59 COV78-36 5-10-1 S2P6 1-46 WT Alpha Beta Gamma Delta Mu Omicron BA.1 Omicron BA.2 Omicron BA.4/5 Concentration (g/mL) † Fig. 1. Broadly neutralizing antibodies target coronaviruses associated with human disease. (A) Analysis of the frequency of MBCs expressing broadly reactive antibodies from 19 donors. Values in ...

COV44-62 Neutralization Curves C D COV44-62 …

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