WebE-selectin, an adhesion molecule exclusively expressed on endothelial cells and activated by cytokines, is an essential component of the vascular niche in the BM microenvironment, where it promotes the proliferation of … WebNov 29, 2024 · The endosteal bone marrow niche is known to protect leukemic stem …
Bone vascular niche E-selectin induces …
WebNov 29, 2024 · The endosteal bone marrow niche is known to protect leukemic stem cells (LSC) from chemotherapy, but the role of the vascular niche in the bone marrow microenvironment in leukemia is largely unknown. E-selectin, which is expressed on bone marrow endothelial cells, has been described to regulate the dormancy of normal … WebE-selectin binding activity mediated by the α1-3 fucosyltransferases Fut3/Fut6 and … inspire morecambe
Vascular E-Selectin Mediates Chemo-Resistance in Acute Myeloid …
WebMar 13, 2024 · Here, we provide evidence suggesting the possible involvement of RUNX transcription factors in the transactivation of E-selectin, a member of selectin family of cell adhesion molecules, on the vascular endothelial cells of the mice bone marrow niche. WebApr 13, 2024 · FIGURE 2. Figure 2 Colorectal CSCs niche components. Colorectal CSCs niche contains different types of cells and microbes, as well as the soluble substances they produce, supporting the self-renewal ability of cancer stem cells. Cancer stem cells can gain a competitive advantage over normal stem cells by promoting differentiation. WebE-selectin binding activity mediated by the α1-3 fucosyltransferases Fut3/Fut6 and Glg1 are instrumental to the formation of bone metastasis. These findings provide unique insights into the functional role of E-selectin as a component of the vascular niche critical for metastatic colonization in bone. inspire moore winery ny